Insulin-like growth factor-I (IGF-I) serum concentrations in healthy children and adolescents: relationship to level of contamination by DDT-derivative pesticides.

CONTEXT Serum levels of Insulin-like growth factor I (IGF-I) play a critical role in children growth and in the pathogenesis of several diseases. In addition, recent studies suggest that DDT-derivative organochlorine pesticides (OC-DDTs) could influence IGF levels in human beings. OBJECTIVE AND DESIGN Because it has been suggested that IGF-I peak levels at puberty could determine IGF-I levels in adulthood, we developed a cross-sectional study of the potential association between serum levels of OC-DDTs and IGF system in 160 serum samples from young people (81 boys and 79 girls) living in the Canary Islands (Spain). RESULTS Multivariate tests were used adjusting for confounding variables (age, height, and weight) and stratifying by gender and age: IGF-I serum levels were significantly lower in pre-pubertal male children (6-15years) who showed detectable values of p,p'-DDE, and p,p'-DDD than in pre-pubertal male children with undetectable levels of these OC-DDTs-metabolites (p=0.023 and p=0.049, respectively). In addition, in this multivariate model, a non-linear dose-response curve was observed between Total DDT body burden (sum of the three DDT-derivatives measured: p,p'-DDT, p,p'-DDE, and p,p'-DDD) and IGF-I in pre-pubertal male children (6-15years; p=0.043). CONCLUSION These findings suggest that OC-DDTs could modulate the IGF-system in a way that is highly influenced by gender and age. Improvements in our understanding of exogenous determinants of the IGF-system may provide new insights into the role played by environmental contaminants in IGF-related diseases.